Canadian Willowherb comes from northern Canadian Prairies plants that have developed strong phytochemical properties to survive the harsh climate. Epilobium angustifolium is a fire succession plant, which means it is among the first plants to regrow after a fire.

Canadian Willowherb contains bioactive molecules such as oenothein B, which has 5-a-reductase inhibitory activity, antioxidant and anti-bacterial properties and its primary function is as a non-steroidal anti-irritant ingredient. In vitro experiments have demonstrated free radical scavenging ability. In addition, it shows strong antibacterial activity on P. acnes. Its anti-irritant and redness reduction properties have been clinically demonstrated, showing a strong reduction of skin redness induced by chemicals or UV exposure within 30 minutes of use.